Table 1.
Demographics data, scores of GSRS, SF-36, and frequency of gene polymorphisms in IBS-D patients and healthy controls
| Controls (n = 64) | IBS-D (n = 62) | p | |
|---|---|---|---|
| Age mean (SD) | 39.7 (14.5) | 43.3 (17.4) | 0.53a |
| Gender male (%) | 42 (65.6) | 40 (64.5) | 0.76b |
| GSRS median (IQL) | |||
| Reflux | 1 (1–1.5) | 2 (1–3) | <0.01c |
| Abdominal pain | 1 (1–1.7) | 3 (1.7–3.9) | <0.01c |
| Indigestion | 1.3 (1–1.8) | 2.4 (1.5–3.5) | <0.01c |
| Diarrhea | 1 (1–1.7) | 5 (3.3–6) | <0.01c |
| Constipation | 1.3 (1–2) | 2.3 (1.7–3) | <0.01c |
| SF-36 NBS mean (SD) | |||
| PF | 55.0 (5.0) | 52.3 (7.5) | 0.02a |
| RP | 48.9 (12.6) | 38.7 (16.7) | <0.01a |
| BP | 53.3 (9.8) | 41.2 (11.6) | <0.01a |
| GH | 52.0 (10.9) | 40.8 (11.6) | <0.01a |
| VT | 48.1 (10.3) | 42.3 (10.8) | <0.01a |
| SF | 49.2 (12.8) | 40.3 (13.3) | <0.01a |
| RE | 47.4 (13.0) | 41.7 (14.9) | 0.03a |
| MH | 49.5 (11.2) | 40.7 (10.7) | <0.01a |
| PCS | 51.9 (9.2) | 44.8 (13.6) | <0.01a |
| MCS | 49.4 (4.5) | 47.7 (3.6) | 0.04a |
| SDS mean (SD) | 36.8 (7.8) | 44.0 (8.9) | <0.01a |
| Genotype | |||
| 5-HTTLPR del(s)/ins(l) s/s, l/s, l/l | 42, 19, 3 | 41, 21, 0 | 0.15b |
| 5-HTT intron2 VNTR 12/12, 10/12rep | 52, 12 | 50, 12 | 0.81b |
| TPH1 rs4537731 -6526 A>G A/A, A/G, G/G | 39, 27, 0 | 41, 20, 1 | 0.38b |
| TPH1 rs211105 intron3 T>G T/T, T/G, G/G | 46, 18, 0 | 48, 13, 1 | 0.41b |
GSRS, gastrointestinal symptom rating scale; SF-36, Short-Form-36; IBS-D diarrhea-predominant irritable bowel syndrome; NBS, norm-based scoring; PF, physical functioning; RP, role physical; BP, bodily pain; GH, general health; VT, vitality; SF, social functioning; RE, role emotional; MH, mental health; PCS, physical component summary; MCS, mental component summary; SDS, Self-rating Depression Scale. P values calculated using a, unpaired t test; b, chi-squared test; c, Mann-Whitney U test.