Table 3.
Association of polymorphisms of TPH1 rs211105, GI symptoms, and QOL scores
| TPH1 rs211105 | Controls |
p | IBS-D |
p | ||
|---|---|---|---|---|---|---|
| T/T (n = 46) | T/G (n = 18) | T/T (n = 48) | T/G (n = 14) | |||
| Age mean (SD) | 40.9 (13.6) | 37.5 (15.3) | 0.89a | 41.7 (17.8) | 51 (14.6) | 0.64a |
| Gender male (%) | 30 (65.2) | 12 (66.7) | 0.92b | 33 (68.7) | 7 (50) | 0.21b |
| GSRS median (IQL) | ||||||
| Reflux | 1 (1–1.5) | 1.5 (1–1.9) | 0.69c | 2 (1–3) | 2 (1–2.5) | 0.76c |
| Abdominal pain | 1 (1–1.7) | 1 (1–1.7) | 0.61c | 2 (1.4–3.5) | 2.2 (1.9–3) | 0.84c |
| Indigestion | 1.3 (1–1.8) | 1.5 (1.1–2.1) | 0.24c | 2.8 (1.5–3.8) | 1.9 (1–2.4) | 0.01c |
| Diarrhea | 1 (1–2) | 1.2 (1–1.7) | 0.92c | 5.3 (3.8–6) | 3.2 (2.3–5.7) | 0.02c |
| Constipation | 1.3 (1–2) | 1.3 (1–1.7) | 0.54c | 2.7 (2–3.3) | 1.8 (1.3–3) | 0.12c |
| SF-36 NBS mean (SD) | ||||||
| PF | 55 (4.9) | 55.1 (5.5) | 0.95a | 52.6 (7.1) | 51.4 (9.1) | 0.58a |
| RP | 48.3 (12.5) | 50.4 (13.3) | 0.56a | 36 (17.3) | 47.2 (11.5) | 0.01a |
| BP | 52.1 (10.6) | 56.2 (6.9) | 0.09a | 40.7 (11.8) | 42.8 (11.2) | 0.56a |
| GH | 52.5 (10.9) | 56.2 (6.9) | 0.67a | 40.2 (11.5) | 42.8 (10.8) | 0.45a |
| VT | 48.3 (11.1) | 47.6 (8.4) | 0.81a | 40.8 (10.8) | 47.2 (9.3) | 0.05a |
| SF | 48 (14) | 52.2 (8.8) | 0.19a | 39.3 (14.4) | 43.5 (8.3) | 0.19a |
| RE | 47.1 (13) | 48.1 (13.4) | 0.80a | 41 (15.2) | 43.8 (14.1) | 0.54a |
| MH | 49 (11.7) | 50.8 (10.2) | 0.59a | 38.7 (10.7) | 47 (8.4) | 0.01a |
| PCS | 51.8 (7.5) | 54.2 (7.1) | 0.34a | 45.7 (12.4) | 49.1 (10.3) | 0.33a |
| MCS | 49.1 (5.7) | 48.9 (5.4) | 0.64a | 48.5 (3.6) | 49.3 (5.4) | 0.58a |
| SDS mean (SD) | 36.7 (8.3) | 36.8 (7.1) | 0.97a | 44.8 (8.5) | 41 (9.9) | 0.19a |
GSRS, gastrointestinal symptom rating scale; SF-36, Short-Form-36; NBS, norm-based scoring; PF, physical functioning; RP, role physical; BP, bodily pain; GH, general health; VT, vitality; SF, social functioning; RE, role emotional; MH, mental health; IBS-D, diarrhea-predominant irritable bowel syndrome; PCS, physical component summary; MCS, mental component summary; SDS, Self-rating Depression Scale. P values calculated using the a, unpaired t test; b, chi-squared test; c, Mann-Whitney U test.