Table 4.
Summary of previously published data (26) of physical and biomechanical features of spinal fusion segments across vitamin D adjusted chow groups.
| Measurement | Deficient Vitamin D (DD) (0 IU/g) Ca = 0.95%* | Insufficient Vitamin D (ID) (2.25 IU/g) Ca = 0.95%* | Sufficient Vitamin D Control (CD) (5 IU/g) Ca = 0.95%* | Hyper-Vitamin D (HD) (40 IU/g) Ca = 0.94%* | P-Value |
|---|---|---|---|---|---|
| Spine MicroCT | |||||
| BMD (sBMD) | 409.98 ± 58.40 | 422.36 ±37.12 | 441.00 ± 40.53 | 483.83 ± 56.50 | p<0.01** |
| Bone Volume (sBV) | 575.58 ± 81.00 | 488.27 ±87.27 | 512.97 ±110.14 | 651.61 ± 162.71 | p<0.01** |
| Bone Volume/Total Volume (sBV/TV) | 0.71 ± 0.09 | 0.74 ± 0.05 | 0.76 ± 0.05 | 0.81 ± 0.05 | p<0.01** |
| Spine Biomechanics | |||||
| Stiffness | 463.99 ± 76.67 | 385.67 ±75.78 | 494.04 ± 86.17 | 503.91 ± 67.44 | NS (p=0.08) |
| Fusion rate (manual palpation) | 45% (5/11) | 58% (7/12) | 61% (8/13) | 83% (10/12) | NS (p=0.08) |
Values given as mean ± SD, NS = Not Significant
% Calcium by weight of rat chow diet
SAS-GLM, ANOVA suggest main effect of dietary Vitamin D with significant group comparisons (Tukey’s HSD):
sBMD, significant effect of dietary Vitamin D (R2=0.25, F= 4.64, p <0.01). There was significantly higher sBMD in hyper-vitamin D (HD) group vs. ID (p<0.05) and HD vs. DD (p<0.05).
sBV, significant effect of dietary Vitamin D (R2=0.25, F= 4.20, p <0.01). There was significantly higher sBV in hyper-vitamin D (HD) group vs. CD (p<0.05) and HD vs. ID (p<0.05).
sBV/TV, significant effect of dietary Vitamin D (R2=0.29, F=5.10, P<0.01) with significantly higher sBV/TV in hyper-vitamin D (HD) group vs. ID (p<0.05) and HD vs. DD (p<0.05).