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Nested SVs in SKBR3 cancer cell line. A: Evaluation of Sniffles + NGMLR using simulated data to identify nested SVs. B: A 3kb region including two deletions flanking an inverted sequence clearly visible and detected by Sniffles using NGMLR (above) and not detected by the Illumina methods (below). C: The start of an inverted duplication. The breakpoints were reported by Sniffles as the start of an inverted duplication (above) and not correctly detected by short-read methods (below).
