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. Author manuscript; available in PMC: 2018 Oct 30.
Published in final edited form as: Nat Methods. 2018 Apr 30;15(6):455–460. doi: 10.1038/s41592-018-0002-6

Figure 2. The sensitivity of the Picky pipeline in SV detection.

Figure 2

(a) Picky accurately defines a short TD. A 12.9 Kb nanopore read aligns to reference genome as two overlapping segments of 11.4 Kb and 2.4 Kb with 86% and 83% identities (e-value = 0). This TD was misclassified as a translocation by the short-read aligner BWA and SV caller LUMPY. (b) A complex SV of two translocations detected by Picky from a 32.5 Kb nanopore read. The alignments were visualized by Ribbon (https://github.com/MariaNattestad/ribbon). (c) Numbers of reference deletions supported by each versus all pipelines among different thresholds.