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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Structure. 2018 Apr 12;26(6):894–904.e2. doi: 10.1016/j.str.2018.03.011

Figure 1. Illustration of integrative modeling.

Figure 1

Examples of experimental and computational methods that can provide spatial restraints for integrative modeling (top). Atomistic and coarse-grained starting structural models of components of a macromolecular assembly are shown in various representations (bottom left). Extensive conformational and/or configurational sampling is carried out to yield the optimized assembly models that satisfy the input spatial restraints (bottom right).