Table 4.
Annulus fibrosus co-regulatory gene networks
| ECM and cell adhesion related genes | Signaling Associated Genes | ||||||
|---|---|---|---|---|---|---|---|
| Gene symbol |
Gene name | Function | Cluster | Gene symbol | Gene name | Function | Cluster |
| ADAM12 | ADAM metallopeptidase domain 12 | ECM | "paleturquoise" | FGF9 | fibroblast growth factor 9 | Growth factor | "paleturquoise" |
| COL5A1 | collagen, type V, alpha 1 | ECM | "paleturquoise" | KREMEN1 | kringle containing transmembrane protein 1 | Wnt signaling | "paleturquoise" |
| COL5A2 | collagen, type V, alpha 2 | ECM | "paleturquoise" | PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | Growth factor | "paleturquoise" |
| COL6A3 | collagen, type VI, alpha 3 | ECM | "paleturquoise" | WISP1 | WNT1 inducible signaling pathway protein 1 | Wnt signaling | "paleturquoise" |
| CDH5 | cadherin 5, type 2 | Adhesion | "darkorange2" | WNT5A | wingless-type MMTV integration site family, member 5A | Wnt signaling | "paleturquoise" |
| CDH6 | cadherin 6, type 2, K-cadherin | Adhesion | "darkorange2" | WNT6 | wingless-type MMTV integration site family, member 6 | Wnt signaling | "paleturquoise" |
| CDH24 | cadherin-like 24 | Adhesion | "darkorange2" | WNT9B | wingless-type MMTV integration site family, member 9B | Wnt signaling | "paleturquoise" |
| COL17A1 | collagen type XVII alpha 1 chain | ECM | "darkorange2" | CDH6 | cadherin 6 | NOTCH signaling | "darkorange2" |
| COL18A1 | collagen, type XVIII, alpha 1 | ECM | "darkorange2" | CDKN1B | cyclin dependent kinase inhibitor 1B | NOTCH signaling | "darkorange2" |
| COL21A1 | collagen, type XXI, alpha 1 | ECM | "darkorange2" | DNER | delta/notch like EGF repeat containing | NOTCH signaling | "darkorange2" |
| COL4A1 | collagen type IV alpha 1 chain | ECM | "darkorange2" | HES5 | hes family bHLH transcription factor 5 | NOTCH signaling | "darkorange2" |
| COL4A2 | collagen type IV alpha 2 chain | ECM | "darkorange2" | HEYL | hes related family bHLH transcription factor with YRPW motif-like | NOTCH signaling | "darkorange2" |
| COL4A5 | collagen type IV alpha 5 chain | ECM | "darkorange2" | HHEX | hematopoietically expressed homeobox | NOTCH signaling | "darkorange2" |
| CNTN4 | contactin 4 | Adhesion | "darkorange2" | HOXD3 | homeobox D3 | NOTCH signaling | "darkorange2" |
| ELN | elastin | ECM | "darkorange2" | IGFBP4 | insulin-like growth factor binding protein 4 | Wnt signaling | "darkorange2" |
| FBLN1 | fibulin 1 | ECM | "darkorange2" | IGFBP6 | insulin-like growth factor binding protein 6 | Wnt signaling | "darkorange2" |
| FBLN5 | fibulin 5 | ECM | "darkorange2" | IGFBP7 | insulin-like growth factor binding protein 7 | Wnt signaling | "darkorange2" |
| ICAM1 | intercellular adhesion molecule 1 | Adhesion | "darkorange2" | JAG1 | jagged 1 | NOTCH signaling | "darkorange2" |
| ICAM2 | intercellular adhesion molecule 2 | Adhesion | "darkorange2" | JAG2 | jagged 2 | NOTCH signaling | "darkorange2" |
| ITGA3 | integrin subunit alpha 3 | Adhesion | "darkorange2" | KCNA5 | potassium voltage-gated channel subfamily A member 5 | NOTCH signaling | "darkorange2" |
| ITGA6 | integrin subunit alpha 6 | Adhesion | "darkorange2" | MAML3 | mastermind like transcriptional coactivator 3 | NOTCH signaling | "darkorange2" |
| ITGA7 | integrin subunit alpha 7 | Adhesion | "darkorange2" | NEURL1B | neuralized E3 ubiquitin protein ligase 1B | NOTCH signaling | "darkorange2" |
| ITGA8 | integrin subunit alpha 8 | Adhesion | "darkorange2" | NOTCH3 | notch 3 | NOTCH signaling | "darkorange2" |
| ITGA9 | integrin subunit alpha 9 | Adhesion | "darkorange2" | NOTCH4 | notch 4 | NOTCH signaling | "darkorange2" |
| ITGB4 | integrin subunit beta 4 | Adhesion | "darkorange2" | NRARP | NOTCH-regulated ankyrin repeat protein | NOTCH signaling | "darkorange2" |
| JAM2 | junctional adhesion molecule 2 | Adhesion | "darkorange2" | PDGFB | platelet-derived growth factor beta polypeptide | Growth factor | "darkorange2" |
| LAMA3 | laminin subunit alpha 3 | Adhesion | "darkorange2" | PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | NOTCH signaling | "darkorange2" |
| LAMA4 | laminin subunit alpha 4 | Adhesion | "darkorange2" | VEGFC | vascular endothelial growth factor C | Growth factor | "darkorange2" |
| LAMA5 | laminin subunit alpha 5 | Adhesion | "darkorange2" | WISP2 | WNT1 inducible signaling pathway protein 2 | Wnt signaling | "darkorange2" |
| LAMB1 | laminin subunit beta 1 | Adhesion | "darkorange2" | WISP3 | WNT1 inducible signaling pathway protein 3 | Wnt signaling | "darkorange2" |
| LAMB1 | laminin subunit beta 1 | Adhesion | "darkorange2" | ZNF423 | zinc finger protein 423 | NOTCH signaling | "darkorange2" |
| MYH9 | myosin heavy chain 9 | Adhesion | "darkorange2" | ||||
| PCDH1 | protocadherin 1 | Adhesion | "darkorange2" | ||||
| PCDH12 | protocadherin 12 | Adhesion | "darkorange2" | ||||
| PCDH17 | protocadherin 17 | Adhesion | "darkorange2" | ||||
| PCDH19 | protocadherin 19 | Adhesion | "darkorange2" | ||||
| TINAGL1 | tubulointerstitial nephritis antigen like 1 | Adhesion | "darkorange2" | ||||
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | ECM | "darkslateblue" | ||||
| CNTN1 | contactin 1 | Adhesion | "darkslateblue" | ||||
| COL5A3 | collagen, type V, alpha 3 | ECM | "darkslateblue" | ||||
| COL6A1 | collagen, type VI, alpha 1 | ECM | "darkslateblue" | ||||
| LAMA1 | laminin, alpha 1 | Adhesion | "darkslateblue" | ||||