Table 5.
Nucleus pulposus co-regulatory gene network
| ECM and cell adhesion related genes | Signaling associated genes | ||||||
|---|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Function | Cluster | Gene symbol | Gene name | Function | Cluster |
| CDH26 | cadherin-like 26 | Adhesion | "black" | CTGF | connective tissue growth factor | Growth factor | "black" |
| CDHR5 | mucin-like protocadherin | Adhesion | "black" | FGFR2 | fibroblast growth factor receptor 2 | Growth factor | "black" |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | Adhesion | "black" | FGFR3 | fibroblast growth factor receptor 3 | Growth factor | "black" |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | ECM | "black" | BMP2 | bone morphogenetic protein 2 | Growth factor | "grey60" |
| COL27A1 | collagen, type XXVII, alpha 1 | ECM | "black" | BMP6 | bone morphogenetic protein 6 | Growth factor | "grey60" |
| COL2A1 | collagen, type II, alpha 1 | ECM | "black" | FGF1 | fibroblast growth factor 1 (acidic) | Growth factor | "grey60" |
| CRTAP | cartilage associated protein | ECM | "black" | FGF2 | fibroblast growth factor 2 (basic) | Growth factor | "grey60" |
| CTGF | connective tissue growth factor | ECM | "black" | GDF6 | growth differentiation factor 6 | Growth factor | "grey60" |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | Adhesion | "black" | HHIP | hedgehog interacting protein | Growth factor | "grey60" |
| GPC6 | glypican 6 | ECM | "black" | IGFBP3 | insulin-like growth factor binding protein 3 | Growth factor | "grey60" |
| ITGA10 | integrin, alpha 10 | Adhesion | "black" | INHBA | inhibin, beta A | Growth factor | "grey60" |
| LMLN | leishmanolysin-like | Adhesion | "black" | NGF | nerve growth factor (beta polypeptide) | Growth factor | "grey60" |
| PCDH20 | protocadherin 20 | Adhesion | "black" | NOG | noggin | Growth factor | "grey60" |
| TESK2 | testis-specific kinase 2 | Adhesion | "black" | PDGFC | platelet derived growth factor C | Growth factor | "grey60" |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | ECM | "grey60" | TGFA | transforming growth factor, alpha | Growth factor | "grey60" |
| CCDC80 | coiled-coil domain containing 80 | ECM | "grey60" | TGFBR1 | transforming growth factor, beta receptor 1 | Growth factor | "grey60" |
| CDH19 | cadherin 19, type 2 | Adhesion | "grey60" | TSHB | thyroid stimulating hormone, beta | Growth factor | "grey60" |
| CHI3L1 | chitinase 3-like 1 | ECM | "grey60" | VEGFA | vascular endothelial growth factor A | Growth factor | "grey60" |
| FN1 | fibronectin 1 | ECM | "grey60" | WNT1 | wingless-type MMTV integration site family, member 1 | Wnt signaling | "grey60" |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | ECM | "grey60" | WNT16 | wingless-type MMTV integration site family, member 16 | Wnt signaling | "grey60" |
| IMPG2 | interphotoreceptor matrix proteoglycan 2 | ECM | "grey60" | WNT9A | wingless-type MMTV integration site family, member 9A | Wnt signaling | "grey60" |
| ITGB5 | integrin, beta 5 | Adhesion | "grey60" | GDF5 | growth differentiation factor 5 | Growth factor | "lightyellow" |
| LAMB3 | laminin, beta 3 | Adhesion | "grey60" | HHIPL1 | HHIP-like 1 | Hedgehog signaling | "lightyellow" |
| LUM | lumican | ECM | "grey60" | HHIPL2 | HHIP-like 2 | Hedgehog signaling | "lightyellow" |
| PRG4 | proteoglycan 4 | ECM | "grey60" | INHA | inhibin, alpha | Growth factor | "lightyellow" |
| SERPINE1 | serpin peptidase inhibitor, clade E member 1 | ECM | "grey60" | NRG4 | neuregulin 4 | Growth factor | "lightyellow" |
| SERPINE2 | serpin peptidase inhibitor, clade E member 2 | ECM | "grey60" | NRTN | neurturin | Growth factor | "lightyellow" |
| SMOC1 | SPARC related modular calcium binding 1 | ECM | "grey60" | ||||
| TIMP2 | TIMP metallopeptidase inhibitor 2 | ECM | "grey60" | ||||
| TIMP3 | TIMP metallopeptidase inhibitor 3 | ECM | "grey60" | ||||
| VCAN | versican | ECM | "grey60" | ||||
| ACAN | aggrecan | ECM | "lightyellow" | ||||
| ADAMTSL2 | similar to ADAMTS-like 2; ADAMTS-like 2 | ECM | "lightyellow" | ||||
| BGN | biglycan | ECM | "lightyellow" | ||||
| CHAD | chondroadherin | Adhesion | "lightyellow" | ||||
| CILP2 | cartilage intermediate layer protein 2 | ECM | "lightyellow" | ||||
| COL11A2 | collagen, type XI, alpha 2 | ECM | "lightyellow" | ||||
| COL9A2 | collagen, type IX, alpha 2 | ECM | "lightyellow" | ||||
| COL9A3 | collagen, type IX, alpha 3 | ECM | "lightyellow" | ||||
| COMP | cartilage oligomeric matrix protein | ECM | "lightyellow" | ||||
| EMILIN3 | elastin microfibril interfacer 3 | ECM | "lightyellow" | ||||
| PRELP | proline/arginine-rich end leucine-rich repeat protein | ECM | "lightyellow" | ||||
| SERPINA1 | serpin peptidase inhibitor, clade A member 1 | ECM | "lightyellow" | ||||
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | ECM | "lightyellow" | ||||