Table 1.
Patient demographics and baseline characteristics
| BI 409306 | Placebo (n = 10) | Total (N = 40) | |||
|---|---|---|---|---|---|
| 25 mg (n = 10) | 50 mg (n = 10) | 100 mg (n = 10) | |||
| Mean age (SD), years | 37.9 (9.5) | 42.5 (9.0) | 42.5 (8.4) | 37.8 (9.5) | 40.2 (9.0) |
| Gender, n (%) | |||||
| Male | 10 (100.0) | 7 (70.0) | 10 (100.0) | 8 (80.0) | 35 (87.5) |
| Female | – | 3 (30.0) | – | 2 (20.0) | 5 (12.5) |
| Race, n (%) | |||||
| African American | 5 (50.0) | 4 (40.0) | 7 (70.0) | 5 (50.0) | 21 (52.5) |
| White | 5 (50.0) | 6 (60.0) | 3 (30.0) | 5 (50.0) | 19 (47.5) |
| BMI, kg/m2 | 26.0 (5.6) | 31.5 (4.3) | 29.1 (6.1) | 28.7 (5.2) | 28.8 (5.5) |
| HVLT-R score | 17.9 (5.5) | 18.4 (3.7) | 16.9 (6.4) | 19.5 (5.2) | 18.2 (5.2) |
| BVMT-R score | 9.2 (10.3) | 17.5 (3.8) | 12.9 (7.9) | 16.2 (10.3) | 14.0 (8.8) |
| Smoking status, n (%) | |||||
| Never smoked | – | 1 (10.0) | 1 (10.0) | 3 (30.0) | 5 (12.5) |
| Ex-smoker | – | 1 (10.0) | 3 (30.0) | – | 4 (10.0) |
| Current smoker | 10 (100.0) | 8 (80.0) | 6 (60.0) | 7 (70.0) | 31 (77.5) |
| Alcohol status, n (%) | |||||
| Non-drinker | 10 (100) | 9 (90.0) | 9 (90.0) | 10 (100.0) | 38 (95.0) |
| Drinks–no interference | – | 1 (10.0) | 1 (10.0) | – | 2 (5.0) |
Treated set includes all patients who received at least 1 dose of study medication
Data are presented as mean (SD), unless indicated otherwise
BMI body mass index, BVMT-R Brief Visuospatial Memory Test–Revised, HVLT-R Hopkins Verbal Learning Test–Revised, SD standard deviation