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Response of (DR2 × Ob1)F1 mice to an acute challenge with MBP. Dose-dependent secretion of cytokines in the serum of (DR2 × Ob1)F1 mice 2 h after subcutaneous injection of MBP (a–d). Data were analyzed by ANOVA followed by Dunnett’s multi-comparison test. *, ** and *** indicate p < 0.05, < 0.01 and < 0.001, respectively, versus the vehicle (PBS)-treated group (n = 4–5). ANOVA analysis of variance, IFN interferon, IL interleukin, MBP myelin basic protein, PBS phosphate-buffered saline
