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. 2018 Feb 25;32(6):1317–1326. doi: 10.1038/s41375-018-0075-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — 123b-33bcCAR T-cells demonstrate targeted lysis of tumor cells lines. All target populations are encircled. a Flow cytometry analysis of control T-cells and 123b-33bcCAR T-cells against MOLM13 (CD123⁺CD33⁺) or U937 (CD123^-CD33 + ) tumor target cells at 2:1 and 5:1 E:T ratios. b Flow cytometry analysis of control T-cells and 123b-33bcCAR T-cells against wild-type (WT) Jurkat tumor cells and Jurkat cells expressing either CD123 (Jurkatxp123) or CD33 (Jurkatxp33) at a 2:1 E:T ratio. c Dose-dependent cultures performed with HL60 (CD123^dimCD33⁺) and KG1a (CD123⁺CD33⁺) cells display high cCAR killing efficiency at E:T ratios ranging from 0.25:1 to 10:1