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Targeting and patterns of somatic hypermutation identified for IgM (A), IgT (B), and IgD (C). Bar charts show the average percentages (mean + SD) of mutations in grade 0 or grade 2 kidneys (n = 4), assessed by analyzing CDR2-FR3 region transcripts encoding the VH4 family from IgM and IgT or VH11 for IgD. Statistical differences (P < 0.05) between the two groups (analyzed with a two-tailed Student’s t-test) are shown with an asterisk.
