Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 31;8:191. doi: 10.3389/fonc.2018.00191

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Hoeman, Shen and Becher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Murine diffuse intrinsic pontine glioma (DIPG) induced by PDGF-A; H3.1K27M; p53 loss. Low (top) and high (bottom) magnification images of a murine DIPG induced with the RCAS/tumor virus A (TVA) system using Nestin TVA; p53 floxed/floxed mice. Neonatal mouse was infected postnatally with DF1 expressing RCAS vectors expressing PDGF-A, H3.1 K27M, and Cre (to delete p53) at a ratio of 1:1:1, and euthanized 43 days’ post-infection. Images from left to right: H&E, Ki-67, HA (tag for H3.1K27M), and Olig2 immunohistochemistry. Note the infiltration into the cerebellum (best seen on low magnification HA and Olig2 immunohistochemistry images).