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. 2018 May 31;9:577. doi: 10.3389/fphar.2018.00577

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Copyright © 2018 Jin, Hu, Chen, Wang, Dong, Zhang, Zhu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of FHND004 on I_Kr recorded from HL-1 cells. (A) Families of hERG current elicited by the voltage protocol shown in the inset. (B) Peak current elicited by the voltage protocol shown in the inset in the absence and presence of 10 μM FHND004. (C,D) I–V relationships for step and tail currents in the absence and presence of 10 μM FHND004, respectively (n = 6). (E) Concentration–response relationships fitted with Logistic equation for block of I_kr tail current by FHND004 (n ≥ 4 per data point); k is 2.21 ± 0.67.