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. 2018 May 31;10:142. doi: 10.3389/fnagi.2018.00142

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Copyright © 2018 Smith, Yao, Chen and Kirby.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Latency to escape in the Barnes maze did not differ on any day of training between pair- and group-housed mice. Day 1: main effect of trial (p = 0.131), main effect of housing (p = 0.604), trial by housing interaction (p = 0.927), effect of subjects (p = 0.680). Day 2: main effect of trial (p = 0.016), main effect of housing (p = 0.224), trial by housing interaction (p = 0.308), effect of subjects (p = 0.076). Day 3: main effect of trial (p = 0.443), main effect of housing (p = 0.855), trial by housing interaction (p = 0.445), effect of subjects (p = 0.080). Day 4: main effect of trial (p =0.012), main effect of housing (p = 0.864), trial by housing interaction (p = 0.254), effect of subjects (p = 0.071). Average ± SEM is shown. (B) The number of mice displaying spatial search strategies was significantly higher in grouped over paired housing. *p = 0.028, Chi² test. Fraction of mice is shown with total number in text within bars.