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. 2018 May 31;11:182. doi: 10.3389/fnmol.2018.00182

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Copyright © 2018 Manzo, O'Conner, Barrows, Shreiner, Birchak and Zarnescu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolomic profiling of ALS larvae uncovers deficits in carnitine, carnitine conjugation and lipid beta oxidation. (A) Carnitine shuttle components and fatty acid import into mitochondria. CPT1, 2, carnitine acyltransferases; CACT, carnitine acylcarnitine transferase; IMM, Inner mitochondrial membrane; OMM, Outer mitochondrial membrane. (B) Summary of significantly altered metabolites in TDP^WT and TDP^G298S compared to w¹¹¹⁸ controls. Green indicates significant downregulation and red indicates significant upregulation (P_value < 0.05).