Figure 3.

Genetic interaction experiments show that CPT1 and CPT2 mitigate locomotor dysfunction caused by TDP^WT and TDP^G298S, in a variant dependent manner. (A) CPT1 knock-down by RNAi (CPT1^RNAi, using y¹v¹; P{y[+t7.7] v[+t1.8] = TRiP.HMS00040}attP2/TM3, Sb¹) mitigates TDP^WT and TDP^G298S larval turning times. (B) CPT2 loss of function (CPT2^f02667, using w¹¹¹⁸; PBac{w[+mC]=WH}CPT2^f02667/TM6B, Tb¹) mitigates TDP^G298S larval turning times. TDP^WT or TDP^G298S were expressed in motor neurons using D42 GAL4. Genotypes as indicated. Kruskal-Wallis multiple comparisons test was used to calculate significance. ^*P_value < 0.05, ^**P_value < 0.01, ^****P_value < 0.0001.