Figure 4.

Medium-chain fatty acids and ketones mitigate TDP-43 dependent locomotor dysfunction in a Drosophila model of ALS. (A,B) Larval turning times, used to measure locomotor deficits caused by TDP^WT or TDP^G298S, are rescued by feeding different medium-chain fatty acids [coconut oil (A) or ethyl heptanoate (B)]. (C) Ketone (beta-hydroxybutyrate) feeding reduces larval turning times in ALS larvae. TDP^WT or TDP^G298S were expressed in motor neurons using D42 GAL4. Genotypes and treatments as indicated. Kruskal-Wallis multiple comparisons test was used to calculate significance. ^*P_value < 0.05, ^**P_value < 0.01, ^***P_value < 0.001, ^****P_value < 0.0001.