Table 1.

Summary of metabolites associated with lipid metabolism in TDP^WT and TDP^G298S compared to w¹¹¹⁸ controls.

		$\frac{TD{P}^{WT}}{w^{1118}}$			$\frac{TD{P}^{G298S}}{w^{1118}}$
Sub pathway	Biochemical name (number of carbons)		P-value	Q-value		P-value	Q-value
Medium chain fatty acid	Caprylate (8:0)	0.91	0.322	0.5054	0.84	0.0947	0.0743
	Caprate (10:0)	1.13	0.1394	0.3364	1.03	0.6364	0.2714
	10-undecenoate (11:1n1)	1	0.881	0.6922	0.94	0.6643	0.2776
	Laurate (12:0)	1.12	0.2719	0.475	1.06	0.4854	0.2304
	5-dodecenoate (12:1n7)	0.88	0.2037	0.4147	0.82	0.0508	0.048
Long chain fatty acid	Myristate (14:0)	1.03	0.7417	0.6697	0.97	0.9668	0.3551
	Myristoleate (14:1n5)	1.02	0.7413	0.6697	1.01	0.7832	0.3091
	Pentadecanoate (15:0)	0.92	0.7983	0.6746	0.77	0.1489	0.1005
	Palmitate (16:0)	0.91	0.4195	0.5696	0.79	0.0435	0.0433
	Palmitoleate (16:1n7)	0.97	0.998	0.7217	0.82	0.2499	0.1445
	Margarate (17:0)	0.76	0.2025	0.4147	0.65	0.0378	0.0396
	10-heptadecenoate (17:1n7)	0.85	0.7824	0.6746	0.68	0.23	0.1364
	Oleate (18:1n9)	0.92	0.7135	0.662	0.77	0.1768	0.112
	Nonadecanoate (19:0)	0.89	0.6763	0.6599	0.9	0.7703	0.307
	10-nonadecenoate (19:1n9)	0.7	0.2182	0.4229	0.73	0.388	0.1938
	7-nonadecenoate (19:1n12)	0.82	0.4783	0.5832	0.62	0.0979	0.0762
	Arachidate (20:0)	0.85	0.4454	0.5755	0.74	0.1622	0.1063
	Eicosenoate (20:1n9 or 11)	0.85	0.6873	0.662	0.7	0.2915	0.1609
	Erucate (22:1n9)	0.77	0.3719	0.5294	0.71	0.219	0.1332
Carnitine metabolism	Carnitine (7)	0.88	0.0035	0.0411	0.86	0.0006	0.0019
Fatty acid metabolism (acyl carnitine)	Acetylcarnitine (9)	0.83	0.01	0.0813	0.74	0.0001	0.0007
	Myristoylcarnitine (21)	1.41	0.0314	0.1641	1.99	0.0001	0.0007
	Palmitoylcarnitine (23)	1.14	0.3647	0.5246	1.41	0.0352	0.038
	Stearoylcarnitine (25)	0.82	0.2075	0.4148	0.93	0.6305	0.2695
	Linoleoylcarnitine (25)	0.95	0.9568	0.7192	1.42	0.0723	0.0612
	Oleoylcarnitine (25)	1.29	0.1606	0.3604	1.55	0.0176	0.0221
Ketone bodies	3-hydroxybutyrate (BHBA) (4)	0.63	0.0137	0.0988	0.56	0.0012	0.003

Altered metabolites in third instar larvae crossed with the motor neuron driver D42 GAL4 were measured using gas or liquid chromatography followed by mass spectrometry. Each biochemical raw output was rescaled to set the median equal to 1. Values for each sample are normalized by Bradford protein concentration. Red and green colored cells indicate statistically significant changes (P-value < 0.05) that are increased and decreased, respectively. Light red and light green colored cells indicate upward or downward trends, respectively (P-value < 0.1). Q-values represent the false discovery rate.