Figure 1.

Lack of RhoA in T-cells reduces experimental autoimmune encephalomyelitis (EAE) disease incidence, onset and severity. (A) Disease incidence in RhoA^fl/flLckCre⁻, RhoA^fl/+LckCre⁺, and RhoA^fl/flLckCre⁺ mice. (B) Day of disease debut of mice from the three different genotypes. (C) EAE disease profile after disease onset in RhoA^fl/flLckCre⁻, RhoA^fl/+LckCre⁺, and RhoA^fl/flLckCre⁺ mice. (D) Overall EAE disease severity in the three different genotypes, represented as the cumulative EAE score over the entire study period. (E) Maximum disease score reached by each mouse throughout the experiment. (F) Mean disease score of each mouse during the acute phase of the disease (days 1–9 after disease debut). RhoA^fl/flLckCre⁻ n = 39, RhoA^fl/+LckCre⁺ n = 13, RhoA^fl/flLckCre⁺ n = 12. Data shown as mean ± SEM. *p < 0.05, **p < 0.01 (Kruskal–Wallis test followed by Dunn’s test).