Table 3. Analysis of Factors Affecting CR.
| Parameters | Univariate logistic regression | Multivariate logistic regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p value | OR | 95% CI | p value | OR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| UCBI+IST (vs. IST) | 0.003 | 3.741 | 1.572 | 8.900 | 0.001 | 5.626 | 1.982 | 15.969 |
| Age (yr) | 0.715 | 0.995 | 0.969 | 1.022 | - | - | - | - |
| Gender (female) | 0.769 | 1.138 | 0.480 | 2.696 | - | - | - | - |
| BMI (kg/m2) | 0.264 | 0.887 | 0.720 | 1.094 | - | - | - | - |
| Interval from first diagnosis to IST (month) | 0.250 | 0.995 | 0.987 | 1.003 | - | - | - | - |
| Etiology (Idiopathic) | 0.665 | 1.500 | 0.239 | 9.420 | - | - | - | - |
| VSAA (vs. SAA) | 0.001 | 0.132 | 0.041 | 0.431 | 0.004 | 0.118 | 0.027 | 0.512 |
| ANC (×109 cell/L) | 0.010 | 16.974 | 1.972 | 146.097 | 0.345 | 2.954 | 0.312 | 27.976 |
| Platelet (×109 cell/L) | 0.234 | 1.023 | 0.986 | 1.062 | - | - | - | - |
| Reticulocyte (×109 cell/L) | 0.522 | 0.991 | 0.963 | 1.020 | - | - | - | - |
| Hemoglobin (g/L) | 0.940 | 1.001 | 0.980 | 1.023 | - | - | - | - |
CR, complete response; CI, confidence interval; OR, odds ratio; IST, immunosuppressive therapy; UCBI, umbilical cord blood infusion; BMI, body mass index; VSAA, very severe aplastic anemia; SAA, severe aplastic anemia; ANC, absolute neutrophil count.
Univariate logistic regression was performed to analyze the factors affecting CR achievement, while factors with p value <0.1 was subsequently analyzed by multivariate model. p value <0.05 was considered significant.