Table 4. Analysis of Factors Affecting ORR.
| Parameters | Univariate logistic regression | Multivariate logistic regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p value | OR | 95% CI | p value | OR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| UCBI+IST (vs. IST) | 0.005 | 4.278 | 1.533 | 11.934 | <0.001 | 10.634 | 2.870 | 39.405 |
| Age (yr) | 0.254 | 0.983 | 0.955 | 1.012 | - | - | - | - |
| Gender (female) | 0.749 | 1.164 | 0.459 | 2.955 | - | - | - | - |
| BMI (kg/m2) | 0.237 | 0.871 | 0.693 | 1.095 | - | - | - | - |
| Interval from first diagnosis to IST (month) | 0.755 | 0.999 | 0.990 | 1.007 | - | - | - | - |
| Etiology (Idiopathic) | 0.617 | 1.770 | 0.189 | 16.592 | - | - | - | - |
| VSAA (vs. SAA) | 0.002 | 0.210 | 0.077 | 0.572 | 0.001 | 0.108 | 0.029 | 0.405 |
| ANC (×109 cell/L) | 0.194 | 4.006 | 0.494 | 32.510 | - | - | - | - |
| Platelet (×109 cell/L) | 0.053 | 1.055 | 0.999 | 1.114 | 0.012 | 1.114 | 1.024 | 1.211 |
| Reticulocyte (×109 cell/L) | 0.550 | 0.991 | 0.963 | 1.021 | - | - | - | - |
| Hemoglobin (g/L) | 0.112 | 1.018 | 0.996 | 1.040 | - | - | - | - |
ORR, overall response rate; CI, confidence interval; OR, odds ratio; IST, immunosuppressive therapy; UCBI, umbilical cord blood infusion; BMI, body mass index; VSAA, very severe aplastic anemia; SAA, severe aplastic anemia; ANC, absolute neutrophil count.
Univariate logistic regression was performed to analyze the factors affecting ORR achievement, while factors with p value <0.1 was subsequently analyzed by multivariate model. in vivo value <0.05 was considered significant.