Figure 3.

Cx26 under external electric field. (A) RMSD on the Cx26 Connexon in absence (green) and presence of an external field (red: negative or polarizing; blue: positive or depolarizing). The external field in either direction was applied after 1 μs of simulation in the absence of an external field. The green trace corresponds to the same simulation presented in Figure 1, which is shown here as a reference. (B) Time series of the maximum constriction size at the pore lumen measured at the level of Lys41 in the absence and in the presence of external field. (C) Solvent accessible surfaces of initial (left) and final conformers colored by chain in top and side views. The color code of the external frames is the same as in (A,B).