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. 2018 May 31;11:170. doi: 10.3389/fnmol.2018.00170

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Copyright © 2018 Zonta, Buratto, Crispino, Carrer, Bruno, Yang, Mammano and Pantano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence alignment around residues 31 and 87 of the 19 human connexins that are known to be translated into proteins. Colors refer to the percentage of consensus, from blue (30%) to red (100%), numbering refers to the amino acid sequence of Cx26. Amino acids in positions 86 always have a small side chain (T, A, C, V, S), with the only exception of Cx40.1 (L). In this connexin, the phenylalanine in position 31 is replaced by a leucine, whose side chain is smaller, assuring that the overall steric hindrance of the two opposed amino acids is conserved along the family.