Table 3.
Enriched biological processes from GO analysis of the loss-of-function genes.
| Term | Gene counts (genes without annotation not shown) | P value | Benjamini |
|---|---|---|---|
| GO:0007186~G protein–coupled receptor signaling pathway | 55 genes including GPR143, OPN3 | 4.56E−12 | 4.64E−09 |
| GO:0002504~antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | DRB, DQA, DQB, LOC100060531 | 8.51E−09 | 4.32E−06 |
| GO:0050907~detection of chemical stimulus involved in sensory perception | 14 genes | 1.28E−04 | 4.25E−02 |
| GO:0006955~immune response | 17 genes including DRB, DQA, DQB, LST1, GZMB, OAS1, EQMHCC1, FAS, EQMHCB2, | 1.77E−04 | 4.39E−02 |
| GO:0002474~antigen processing and presentation of peptide antigen via MHC class I | 5 genes including EQMHCC1, EQMHCB2 | 7.49E−04 | 1.41E−01 |
| GO:0007165~signal transduction | 21 genes including PLPP5,PPP2R5C, CD83, GABRR1, SMOC1, GUCY1A3, GUCY1B3, UNC5D | 4.33E−03 | 5.20E−01 |
| GO:0007608~sensory perception of smell | 13 genes | 1.15E−02 | 8.12E−01 |
| GO:0035518~histone H2A monoubiquitination | KDM2B, CUL4B, PCGF1 | 3.75E−02 | 9.92E−01 |
| GO:0090179~planar cell polarity pathway involved in neural tube closure | WNT5A, DVL3, SFRP1 | 4.49E−02 | 9.94E−01 |
| GO:0019882~antigen processing and presentation | 4 genes | 5.16E−02 | 9.95E−01 |
| GO:0006952~defense response | CD83, DEFA5L, DEFA3, DEFA31L, DEFA16 | 5.95E−02 | 9.97E−01 |
| GO:0046322~negative regulation of fatty acid oxidation | ACADVL, SIRT4 | 6.19E−02 | 9.96E−01 |
| GO:0033182~regulation of histone ubiquitination | UBE2N, LOC102150222 | 6.19E−02 | 9.96E−01 |
| GO:0031058~positive regulation of histone modification | UBE2N, LOC102150222 | 6.19E−02 | 9.96E−01 |
| GO:0055123~digestive system development | WDR19, WDPCP | 6.19E−02 | 9.96E−01 |
| GO:0071346~cellular response to interferon gamma | WNT5A, CCL19, NOS2, DAPK1 | 8.41E−02 | 9.99E−01 |
| GO:0050821~protein stabilization | DVL3, LAMP2, PFN2, WFS1, STXBP4, CSN3, USP13 | 8.49E−02 | 9.98E−01 |
| GO:0051443~positive regulation of ubiquitin-protein transferase activity | UBE2N, LOC102150222, LOC100058286 | 8.85E−02 | 9.98E−01 |
| GO:2000360~negative regulation of binding of sperm to zona pellucida | OVGP1, ASTL | 9.14E−02 | 9.98E−01 |
| GO:0042991~transcription factor import into nucleus | IPO9, SYK | 9.14E−02 | 9.98E−01 |
| GO:0016485~protein processing | APH1A, LOC100050554, GZMB, LOC100061896, CPN1 | 9.40E−02 | 9.97E−01 |
| GO:0035556~intracellular signal transduction | SRPK2, DVL3, ARHGEF3, MKNK2, ASB11, SOCS7, MYO9A, DAPK1, HUNK, RPS6KA3, AIDA, GUCY1A3, GUCY1B3 | 9.91E−02 | 9.97E−01 |
Abbreviation: GO, gene ontology.