Table 1.

Summary of the chromatin remodelers in Drosophila melanogaster known to affect alcohol-induced neuroadaptation.

Protein name	Gene symbol	Molecular function	Substrate specificity	Mutant phenotype	Human homologue	References
Sir2/Sirt1	Sirt1	Sirtuin, histone deacetylase activity	H3	Enhanced tolerance	SIRT1	Engel et al60
CBP	Nej	Histone acetyltransferase activity	H3, H4	Reduced tolerance	CREBBP	Ghezzi et al61
NO66	NO66	Histone demethylase activity	H3K4, H3K36	Enhanced tolerance	RIOX1	Pinzón et al62
KDM3	JHDM2	Histone demethylase activity	H3K9	Reduced tolerance	KDM3	Pinzón et al62
LID	Lid	Histone demethylase activity	H3K4	Enhanced tolerance	KDM5	Pinzón et al62
HSPBAP1	CG12879	Histone demethylase activity	H3K4, H3K36	Reduced tolerance	HSPBAP1	Pinzón et al62

Shown are their molecular functions, substrate specificity, mutant alcohol phenotype, their human homologues, and the publications demonstrating their role in the alcohol phenotypes in Drosophila.