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. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: Prostate Cancer Prostatic Dis. 2018 Mar 20;21(1):126–136. doi: 10.1038/s41391-018-0035-z

Fig. 4 — Characterization of immune response in most effective treatment groups. a Cytokine profile of CD4⁺ and CD8⁺ lymphocytes in spleen. b Expression of immune check point molecules on CD4⁺ and CD8⁺ lymphocytes in spleen. c Cytokine profile of CD4⁺ and CD8⁺ tumor infiltrating lymphocytes. d Expression of immune checkpoint molecules on tumor infiltrating lymphocytes. Data are presented as scatter plots with mean, each data point represents a sample made by combining 2 mice from same treatment group, means were compared by t test, significance of linear trend between means and treatment groups was tested by test for linear trend. *p < 0.05,**p < 0.01, ***p < 0.001 for t test. ^†p < 0.05, ^††p < 0.01, ^†††p < 0.001, for test for linear trend

Fig. 4 — Characterization of immune response in most effective treatment groups. a Cytokine profile of CD4⁺ and CD8⁺ lymphocytes in spleen. b Expression of immune check point molecules on CD4⁺ and CD8⁺ lymphocytes in spleen. c Cytokine profile of CD4⁺ and CD8⁺ tumor infiltrating lymphocytes. d Expression of immune checkpoint molecules on tumor infiltrating lymphocytes. Data are presented as scatter plots with mean, each data point represents a sample made by combining 2 mice from same treatment group, means were compared by t test, significance of linear trend between means and treatment groups was tested by test for linear trend. *p < 0.05,**p < 0.01, ***p < 0.001 for t test. ^†p < 0.05, ^††p < 0.01, ^†††p < 0.001, for test for linear trend