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. 2018 Jun 6;38(23):5415–5428. doi: 10.1523/JNEUROSCI.1653-17.2018

Figure 4.

Figure 4.

HD mice have increased ARMS levels and impaired BDNF release, which is partially rescued upon ARMS knockdown. A, Increased ARMS expression in the hippocampus of 8-month-old KI mice (n = 6). A representative blot is shown. Unpaired Student's t test, mean ± SEM. WT versus KI, t = 2.50, df = 10. B, Impaired BDNF secretion in the hippocampus of KI mice and partial rescue by depleting increased ARMS expression (n = 5 and n = 7 for WT and KI mice, respectively). Unpaired Student's t test, mean ± SEM. WT versus KI mice, shC: K+ Depol: t = 9.249, df = 10; NT-3: t = 10.98, df = 10; NT-4: t = 6.643, df = 10; WT versus KI mice, shARMS-1: K+ Depol: t = 3.518, df = 10; NT-3: t = 2.281, df = 10; NT-4: t = 1.925, df = 10. C, Increased ARMS expression in the hippocampus of 20- to 30-week-old R6/1 mice (n = 7 and n = 4; for WT and R6/1, respectively). A representative blot is shown. Unpaired Student's t test, mean ± SEM. WT versus R6/1, t = 5.842, df = 9. D, Impaired BDNF secretion in the hippocampus of R6/1 HD mice and partial rescue by depleting increased ARMS expression (n = 4). Unpaired Student's t test, mean ± SEM. WT versus R6/1 mice, shC: K+ Depol: t = 3.270, df = 6; NT-3: t = 5.852, df = 6; NT-4: t = 3.927, df = 6; WT versus R6/1 mice, shARMS-1: K+ Depol: t = 2.840, df = 6; NT-3: t = 3.390, df = 10; NT-4: t = 13.46, df = 6. See also Figure 4-1.