. 2018 May 21;24:3348–3356. doi: 10.12659/MSM.910350

Table 4.

Effects of oral magnolol and honokiol administration on the mRNA expression of nitric oxide synthases and inflammatory cytokines in mice (n=10).

Item^*	Treatment^**									SEM^#	P-value
	NC	MC	PC	M			H				P-value
	NC	MC	PC	100	300	500	100	300	500		M	H	M × H
iNOS	1.00^b	1.88^ab	2.60^a	1.64^b	1.37^b	1.01^b	1.64^b	1.60^b	1.25^b	0.443	0.004	0.214	<0.001
TNF-α	1.00	1.74	1.54	1.43	1.18	1.09	1.27	0.89	1.06	0.386	0.418	0.049	0.004
IFN-γ	1.00^c	2.08^a	1.53^abc	1.99^ab	0.89^c	0.78^c	1.51^abc	1.21^bc	1.06^c	0.366	<0.001	0.081	<0.001
IL-6	1.00^ab	1.29^ab	0.60^b	1.38^a	0.93^ab	0.82^ab	1.26^ab	1.08^ab	0.78^ab	0.310	0.018	0.071	0.001
IL-10	1.00^d	4.04^a	2.63^abc	3.12^ab	2.21^bcd	0.74^d	2.73^ab	2.10^bcd	1.17^cd	0.691	<0.001	<0.001	<0.001

iNOS – nitric oxide synthases; TNF-α – tumor necrosis factor alpha; IFN-γ – interferon gamma; IL-6 – interleukin 6; IL-10 – interleukin 10.

^**

In a row, the mean values with different letters (a–d) differ (P<0.05).

NC – normal control; MC – diarrhea model control; PC – positive drug control; M – magnolol administration at the doses of 100, 300, and 500 mg/kg BW; H – Honokiol administration at the doses of 100, 300, and 500 mg/kg BW.

Standard error of least squares means.