Table 1.
Results of the window-based tests for the nine BD-associated miRNAs.
| miRNA [position] | n SNPs | p miRNA | pcorr miRNA | Top SNP [position] | p Top SNP |
|---|---|---|---|---|---|
| A) Dichotomous Treatment Response Measure | |||||
| miR-499a [chr20:34990376-34990497] | 87 | 1.71E-02 | 9.31E-01 | rs117616040 [chr20:34977725] | 2.27E-03 |
| miR-135a-1 [chr3:52294219-52294308] | 41 | 9.29E-02 | 9.31E-01 | rs699465 [chr3:52276426] | 1.98E-02 |
| let-7g [chr3:52268278-52268361] | 44 | 1.04E-01 | 9.31E-01 | rs699465 [chr3:52276426] | 1.98E-02 |
| miR-644a [chr20:34466325-34466418] | 35 | 2.03E-01 | 9.37E-01 | rs7266300 [chr20:34449603] | 9.76E-03 |
| miR-708 [chr11:79402022-79402109] | 130 | 3.51E-01 | 9.50E-01 | rs12275848 [chr11:79416285] | 7.89E-02 |
| miR-1908 [chr11:61815161-61815240] | 39 | 4.33E-01 | 9.50E-01 | rs61897792 [chr11:61819414] | 3.46E-02 |
| miR-640 [chr19:19435063-19435158] | 44 | 6.08E-01 | 9.55E-01 | rs79954596 [chr19:19437834] | 1.74E-01 |
| miR-611 [chr11:61792495-61792561] | 33 | 6.36E-01 | 9.55E-01 | rs17762402 [chr11:61785729] | 4.94E-02 |
| miR-581 [chr5:53951504-53951599] | 55 | 6.41E-01 | 9.55E-01 | rs72644081 [chr5:53949850] | 5.45E-02 |
| B) Continuous Treatment Response Measure | |||||
| miR-499a [chr20:34990376-34990497] | 87 | 3.18E-02 | 7.52E-01 | rs117616040 [chr20:34977725] | 3.73E-03 |
| miR-708 [chr11:79402022-79402109] | 130 | 7.37E-02 | 8.02E-01 | rs1355423 [chr11:79420556] | 2.05E-02 |
| miR-611 [chr11:61792495-61792561] | 33 | 9.79E-02 | 8.22E-01 | rs174532 [chr11:61781402] | 3.30E-03 |
| miR-644a [chr20:34466325-34466418] | 35 | 1.95E-01 | 8.50E-01 | rs7266300 [chr20:34449603] | 6.47E-02 |
| miR-1908 [chr11:61815161-61815240] | 39 | 2.45E-01 | 8.64E-01 | rs968567 [chr11:61828092] | 3.20E-02 |
| miR-640 [chr19:19435063-19435158] | 45 | 2.69E-01 | 9.52E-01 | rs79954596 [chr19:19437834] | 1.15E-02 |
| let-7g [chr3:52268278-52268361] | 44 | 6.40E-01 | 9.81E-01 | rs58315325 [chr3:52261812] | 2.80E-02 |
| miR-135a-1 [chr3:52294219-52294308] | 41 | 7.81E-01 | 9.86E-01 | rs34135146 [chr3:52279416] | 6.28E-02 |
| miR-581 [chr5:53951504-53951599] | 55 | 9.22E-01 | 7.52E-01 | rs697112 [chr5:53964849] | 1.61E-01 |
microRNAs (miRNAs) are sorted according to their miRNA-based P-value. Genome build used is GRCh38 (hg38). Abbreviations: miRNA, microRNA; position, genomic position; nSNPs, number of investigated SNPs; p miRNA, miRNA-based P-value; pcorr miRNA, Benjamini-Hochberg corrected miRNA-based P-value; Top SNP, top single-nucleotide polymorphism within gene; p Top SNP, P-value of the Top SNP within gene.