Table 2.
Results of the window-based tests for the top five genome-wide miRNAs.
| miRNA [position] | n SNPs | p miRNA | pcorr miRNA | Top SNP [position] | p Top SNP |
|---|---|---|---|---|---|
| A) Dichotomous Treatment Response Measure | |||||
| miR-607 [chr10:96828669-96828764] | 48 | 5.79E-04 | 9.31E-01 | rs111682442 [chr10:96823685] | 2.73E-04 |
| miR-8085 [chr19:44758657-44758721] | 44 | 2.54E-03 | 9.31E-01 | rs7249244 [chr19:44742441] | 1.11E-04 |
| miR-1296 [chr10:63372957-63373048] | 62 | 4.13E-03 | 9.31E-01 | rs10995527 [chr10:63387659] | 5.47E-03 |
| miR-4535 [chr22:48780295-48780353] | 160 | 4.62E-03 | 9.31E-01 | rs131016 [chr22:48775746] | 1.24E-03 |
| miR-451b [chr17:28861371-28861438] | 44 | 5.11E-03 | 9.31E-01 | rs34901720 [chr17:28852500] | 2.17E-03 |
| B) Continuous Treatment Response Measure | |||||
| miR-633 [chr17:62944215-62944312] | 29 | 9.80E-04 | 7.52E-01 | rs1588368 [chr17:62938848] | 1.21E-04 |
| miR-6516 [chr17:77089417-77089497] | 183 | 1.97E-03 | 8.02E-01 | rs2411054 [chr17:77074245] | 2.68E-05 |
| miR-218-1 [chr4:20528275-20528384] | 105 | 2.13E-03 | 8.22E-01 | rs540146 [chr4:20544433] | 6.08E-04 |
| miR-7704 [chr2:176188843-176188901] | 68 | 2.20E-03 | 8.50E-01 | rs7589870 [chr2:176208720] | 1.26E-03 |
| miR-548e [chr10:110988926-110989013] | 54 | 2.48E-03 | 8.64E-01 | rs1327551 [chr10:111008438] | 1.09E-03 |
microRNAs (miRNAs) are sorted according to their miRNA-based P-value. Genome build used is GRCh38 (hg38). Abbreviations: miRNA, microRNA; position, genomic position; nSNPs, number of investigated SNPs; p miRNA, miRNA-based P-value; pcorr miRNA, Benjamini-Hochberg corrected miRNA-based P-value; Top SNP, top single-nucleotide polymorphism within gene; p Top SNP, P-value of the Top SNP within gene.