Figure 3.

cG8 and mTTR inhibit the aggregation of Aβ_1–42 and amylin but not α-synuclein. Aβ_1–42 (A), amylin (B), and α-synuclein (C), all at 20 μM final concentration, were combined with cG8 (horizontal lines) or mTTR (vertical lines) at inhibitor/amyloid protein ratios of 1:10 (white bars, black lines), or 1:20 (black bars, white lines) and compared to control (white bars, amyloid protein with no added inhibitor). Aggregation was monitored via ThT fluorescence and data was blank (ThT in PBS) subtracted then normalized to the respective control at 48 h. Error bars indicate SEM, n=2–4. *p<0.05 vs. control.