Figure 6.

Mapping of GeneChip expression data onto existing pathways. To obtain insights into the effects of HCA-SX supplementation, results of GeneChip analysis were mapped onto known pathways associated with energy metabolism and obesity. GenMAPP and KEGG were used as the database for existing pathways. Several of the genes that were upregulated following HCA-SX supplemented were found to overlap with the monoamine G-protein-coupled receptors (GPCR) pathway. Genes shown with arrows were upregulated in the HCA-SX-supplemented group compared with the control groups. Gi/Go, Gq/G11, and Gs pathways: GPCRs have been shown to stimulate signaling cascade through a number of linear pathways that are initiated by s, Gi/Go, Gq/11, or Gs proteins.