TABLE 2.
GENES UPREGULATED FOLLOWING HCA-SX SUPPLEMENTATION
| Gene Name | FC Average | FC SD | Function |
|---|---|---|---|
| Prostaglandin D synthase* | 19.6 | 6.9 | lipid metabolism |
| PDZ domain containing 1 | 14.3 | 2.8 | serotonin receptor signaling |
| Aldolase B* | 12.8 | 1.7 | carbohydrate metabolism |
| Tumor-associated calcium signal transducer 1* | 11.4 | 2.5 | other |
| Asialoglycoprotein receptor 1 | 10.8 | 3.4 | other |
| Preproenkephalin, related sequence | 10.5 | 2.4 | neuropeptide signaling |
| Protease, serine, 8 (prostasin) | 9.8 | 3.8 | enzyme |
| Fructose-1,6-bisphosphatase 1 | 9.2 | 0.8 | glycolysis |
| CD24 antigen* | 0.1 | 4.0 | other |
| Tektin 1 | 8.6 | 1.8 | cytoskeletal |
| Lipocalin 2 | 8.0 | 0.8 | transporter |
| Gonadotropin-regulated long chain acyl-CoA synthetase* | 7.9 | 0.8 | other |
| Low-density lipoprotein receptor-related protein 2* | 6.3 | 1.4 | lipid metabolism |
| Serum amyloid P-component* | 4.9 | 0.6 | other |
| ATPase Na+/K+ transporting beta 1 polypeptide* | 4.9 | 0.5 | transporter |
| Solute carrier family 27 (fatty acid transporter)* | 3.9 | 0.3 | lipid transporter |
| Lipopolysaccharide binding protein | 3.5 | 0.3 | lipid transporter |
| Secretin receptor | 3.3 | 0.5 | other |
| Mucin and cadherin-like* | 2.9 | 0.1 | other |
| Solute carrier family 7, member 9* | 2.7 | 0.4 | transporter |
| Rat submaxillary gland S1 kallikrein mRNA | 2.7 | 0.3 | other |
| Solute carrier family 9* | 2.6 | 0.1 | transporter |
| Tissue-type transflutaminase* | 2.5 | 0.2 | enzyme |
| Sodium channel, nonvoltage-gated 1* | 2.3 | 0.3 | ion channel |
| Glutathione S-transferase, mu 5* | 2.2 | 0.3 | xenobiotic metabolism |
| Voltabe-dependent calcium channel | 1.9 | 0.2 | ion channel |
| Cytochrome P450, subfamily 2E, polypeptide 1* | 1.8 | 0.1 | xenobiotic metabolism |
| Heat-responsive protein 12* | 1.6 | 0.1 | other |
| Kidney-specific membrane protein | 1.6 | 0.4 | other |
| ATPase, Na+K+ transporting, alpha 1* | 1.3 | 0.3 | transporter |
| Kynurenine aminotransferase 2* | 1.3 | 0.1 | enzyme |
| Solute carrier family 3, member 1 | 1.2 | 0.1 | transporter |
| ATPase Na+K+ transporting, alpha 1* | 1.0 | 0.2 | transporter |
| Ceruloplasmin | 0.9 | 0.2 | iron binding |
| Gap junction membrane channel protein alpha 4* | 0.9 | 0.1 | cell communication |
| Tissue-type transglutaminase* | 0.8 | 0.0 | enzyme |
| Peptidylprolyl isomerase C-associated protein* | 0.7 | 0.1 | receptor |
| Ceruloplasmin | 0.7 | 0.1 | iron binding |
| Transmembrane 4 superfamily member 3 | 0.6 | 0.1 | other |
| Small inducible cytokine subfamily A11 | 0.5 | 0.0 | cytokine |
| 5-Hydroxytryptamine (serotonin) receptor 2A† | 1.3 | 0.2 | serotonin receptor |
| 5-Hydroxytryptamine (serotonin) receptor 3a† | 1.3 | 0.3 | serotonin receptor |
| 5-Hydroxytryptamine (serotonin) receptor 2B† | 1.3 | 0.2 | serotonin receptor |
| 5-Hydroxytryptamine (serotonin) receptor 4† | 2.5 | 0.3 | serotonin receptor |
| 5-Hydroxytryptamine (serotonin) receptor 7† | 5.9 | 4.4 | serotonin receptor |
FC, fold change; SD, standard deviation.
*
Gene common in analysis I and II (see Fig. 3).
†
Obesity-related genes identified using Mann-Whitney test.