TABLE 1.

SR31747A AND STANDARD ANTICANCER DRUGS DOSES USED FOR TRANSCRIPTIONAL PROFILING IN THE DIFFERENT CELL LINES STUDIED

	PC-3	DU-145	MDA-MB-231
Taxol	200 nM	100 nM	100 nM
Vincristine	50 nM	50 nM	50 nM
5-FU	50 μM	20 μM	not active
MTX	100 nM	200 nM	not active
Melphalan	30 μM	30 μM	30 μM
Etoposide	not active	5 μM	10 μM
Doxorubicin	2 μM	2 μM	5 μM
SR31747A	30 μM	30 μM	30 μM

IC₇₀ doses were defined in the antiproliferative assays as described in Materials and Methods.