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. 2018 Feb 13;98(6):834–845. doi: 10.1093/biolre/ioy040

Figure 1.

Figure 1.

Differentially expressed miRNA and long RNA transcripts in myometrial specimens in term and preterm labor. (A) Heat map of differentially expressed miRNA transcripts comparing: (1) term labor (TL) to term birth in absence of labor (TNL); and (2) spontaneous preterm birth (PTB) with clinical and/or histologic chorioamnionitis (PTB-HCA) to PTB without labor (PTB-NL). (B) Three-dimensional scatterplot of PCA results for miRNA-seq data. (C) Heat map of differentially expressed long RNA transcripts (TL vs. TNL, and PTB-HCA vs. PTB-NL). (D) PCA results for the long RNA-seq data. Note that the TL samples (purple triangles) clustered distinctly from TNL (green triangles) and PTB-NL (blue circles) specimens, whereas the PTB-HCA samples (red circles) clustered heterogeneously among the laboring and nonlaboring specimens. (E) Scatterplot and linear regression analysis comparing the first PC of the miRNA-seq dataset with that of the long RNA-seq data. Two nonoverlapping molecular clusters were identified: Cluster Q (quiescent, n = 13), and Cluster NQ (nonquiescent, n = 7), which corresponded with clinical records identifying whether or not strong uterine contractions had been documented prior to Cesarean delivery.