TABLE 1.
Comparison of postprandial plasma biomarker AUCs at week 0 in healthy obese and nonobese premenopausal women after consuming either low-fat yogurt or control food followed by the baseline challenge meal1
| Week 0 | Significance (P)2 | ||||||
|---|---|---|---|---|---|---|---|
| AUC0–4h | CN | YN | CO | YO | Obesity | Treatment | Interaction |
| sCD14 (ng/mL · h) | 5490 ± 180 | 5330 ± 210 | 5570 ± 170 | 5460 ± 200 | 0.59 | 0.48 | 0.92 |
| LBP (μg/mL · h) | 39.4 ± 3.7 | 36.4 ± 2.2 | 49.5 ± 2.9 | 47.4 ± 3.6 | 0.0012 | 0.42 | 0.90 |
| LBP:sCD14 | 29.8 ± 3.0 | 28.3 ± 1.8 | 37.2 ± 2.7 | 36.3 ± 2.9 | 0.0045 | 0.64 | 0.91 |
| IL-6 (pg/mL · h) | 4.21 ± 0.40 | 4.45 ± 0.44 | 8.21 ± 0.68 | 8.05 ± 0.77 | 0.0001 | 0.95 | 0.73 |
| Glucose (mg/dL · h) | 299.5 ± 7.9 | 317.4 ± 8.3 | 375.5 ± 10.5 | 346.8 ± 6.7 | 0.0001 | 0.72 | 0.40 |
| TG (mg/dL · h) | 390.0 ± 25.7 | 393.8 ± 35.3 | 528.9 ± 39.4 | 540.6 ± 45.1 | 0.0002 | 0.83 | 0.92 |
1Data are means ± SEMs, n = 30. CN, control nonobese; CO, control obese; LBP, LPS-binding protein; sCD14, soluble CD14; YN, yogurt nonobese; YO, yogurt obese.
2The effects of obesity status (obese compared with nonobese), dietary treatment (low-fat yogurt compared with control food), and the obesity × treatment interaction on week 0 AUC were determined by 2-factor ANOVA (PROC GLM).