Network Co-Activity Observed After Cocaine: Pearson r values reflect the strength of co-activation of Fos expression amongst measured brain regions and subregions: Nucleus Accumbens (core, shell), frontal cortex (PLC, ILC), amygdala (CeA, BLA), epithalamus (LHb, MHb), and hypothalamic orexin neuron subregions (LH, PFA, DMH). Significance level is shown with stars and cell color: *p < .05, yellow; **p < .01, orange; ***p < .001, red. Inset represents measured brain regions, connected with dashed lines between co-activated regions.