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Schematic illustration of sex biased CRF/CRF1 signaling in response to stress can result in sex differentiation of the cortical phospho-proteome and translate to sex distinct impact on neuropathology of AD (red-female, blue-male). Whether other signaling pathways of CRF/CRF1 downstreams (brown) also display sex difference after stress is unknown. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
