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. 2018 May 31;9:571. doi: 10.3389/fphar.2018.00571

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Copyright © 2018 Cui, Cai, Wang, Jia, Li, Zhao, Chu, Lin, Zhang, Bian and Zhuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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General statements of mice were not affected after antibiotics treatment. (A) Antibiotics treatment decreased the total DNA of gut microbiota in mice fecal sample; (B) H&E staining (20x) indicated the antibiotics treatment could not affected the morphology of liver (a), kidney (b), small intestine (c), and colon (d); (C) Liver index (a), colon length (b), and serum ALT (c), AST (d), Cr (e), BUN (f) levels were not changed after antibiotics treatment. Data are presented as mean ± SD. ^∗p < 0.05, ^∗∗p < 0.01. n.s., not statistically significant.