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. 2018 Jun 6;13(6):e0198691. doi: 10.1371/journal.pone.0198691

Table 1. Clinical data.

Subject Age
(years)
Disease duration
(years)
LEDD
(mg)
UPDRS-III
(score)
Pre-DBS Post-DBS Pre-DBS Post-DBS
Meds-off Meds-on Meds-off stim-off Meds-off
stim-on
Meds-on stim-off Meds-on stim-on
wue03 61 18 2725 600 40 9 45 17 23 14
wue09 55 19 1200 730 50 11 33 16 8 11
wue04 54 7 658 400 26 8 27 5 9 8
wue02 65 10 1100 800 40 23 39 19 17 16
wue10 56 10 1200 550 69 14 65 25 20 5
wue07 61 10 650 220 43 24 29 15 8 9
wue06 51 11 1133 180 46 11 48 12 11 6
wue11 53 11 1300 460 55 4 51 9 13 14

Patients were evaluated with the UPDRS-III within one month prior to the implants (pre-DBS) after overnight (>12 h) suspension of all dopaminergic drugs (meds-off) and upon receiving 1 to 1.5-times (range 200–300 mg) the levodopa-equivalent of the morning dose (meds-on). After surgery (post-DBS), patients were also assessed with the UPDRS-III in four conditions: (i) stimulation off for at least two hours (stim-off); (ii) bilateral STN stimulation (stim-on); (iii) meds-on (as pre-DBS); (iv) meds-on and stim-on. Wue11 is the only female patient. DBS, deep brain stimulation; LEDD, levodopa equivalent daily dose; STN, subthalamic nucleus; UPDRS-III, Unified Parkinson Disease Rating.