Table 1. Clinical data.
Subject | Age (years) |
Disease duration (years) |
LEDD (mg) |
UPDRS-III (score) |
||||||
---|---|---|---|---|---|---|---|---|---|---|
Pre-DBS | Post-DBS | Pre-DBS | Post-DBS | |||||||
Meds-off | Meds-on | Meds-off stim-off | Meds-off stim-on |
Meds-on stim-off | Meds-on stim-on | |||||
wue03 | 61 | 18 | 2725 | 600 | 40 | 9 | 45 | 17 | 23 | 14 |
wue09 | 55 | 19 | 1200 | 730 | 50 | 11 | 33 | 16 | 8 | 11 |
wue04 | 54 | 7 | 658 | 400 | 26 | 8 | 27 | 5 | 9 | 8 |
wue02 | 65 | 10 | 1100 | 800 | 40 | 23 | 39 | 19 | 17 | 16 |
wue10 | 56 | 10 | 1200 | 550 | 69 | 14 | 65 | 25 | 20 | 5 |
wue07 | 61 | 10 | 650 | 220 | 43 | 24 | 29 | 15 | 8 | 9 |
wue06 | 51 | 11 | 1133 | 180 | 46 | 11 | 48 | 12 | 11 | 6 |
wue11 | 53 | 11 | 1300 | 460 | 55 | 4 | 51 | 9 | 13 | 14 |
Patients were evaluated with the UPDRS-III within one month prior to the implants (pre-DBS) after overnight (>12 h) suspension of all dopaminergic drugs (meds-off) and upon receiving 1 to 1.5-times (range 200–300 mg) the levodopa-equivalent of the morning dose (meds-on). After surgery (post-DBS), patients were also assessed with the UPDRS-III in four conditions: (i) stimulation off for at least two hours (stim-off); (ii) bilateral STN stimulation (stim-on); (iii) meds-on (as pre-DBS); (iv) meds-on and stim-on. Wue11 is the only female patient. DBS, deep brain stimulation; LEDD, levodopa equivalent daily dose; STN, subthalamic nucleus; UPDRS-III, Unified Parkinson Disease Rating.