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. 2018 Jun 7;11:34. doi: 10.1186/s13039-018-0384-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Type I and Type IV CCR Hexavalent Configurations. Different hexavalent configurations in case of: a type I CCR, as determined by previous analyses, and b type IV CCR, as refined by whole-genome mate-pair sequencing in the current study. The additional breakpoint as well as possible recombination at the “middle segment” in type IV CCR increases the percentage of unbalanced gametes, and subsequently, reproductive risk. Genetic material from chromosomes 6, 7, and 10 are illustrated in orange, blue, and purple lines, respectively