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. 2018 Jun 7;13:12. doi: 10.1186/s13064-018-0109-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Molecular cues guide partner selection of inhibitory neurons. a Schematic showing the lamination of GABAergic-dopaminergic amacrine cells (DACs) and glycinergic AII amacrine cells together with their synaptic partners in wildtype (WT), Sema5A/6A double knockout mutants (dKO) and Sema6A knockouts (KO). T2 BC: Type 2 bipolar cell, M1: melanopsin-expressing retinal ganglion cell, RBC: rod bipolar cell, RGC: retinal ganglion cell, ON: inner sublamina of the retinal plexiform layer, OFF: outer sublamina of the retinal plexiform layer, INL: inner nuclear layer, OPL: outer plexiform layer. Summarized from [18, 19]. Question mark indicates non-examined synaptic partners. b Organization of inhibitory connections in the spinal cord sensory-motor circuit. Distinct populations of inhibitory neurons (G1 and G2) target sensory afferent terminals (SN) and motor neurons (MN), respectively, in WT mice. When sensory afferents are eliminated in PV cre/Isl2-DTA mice, G1 neurons do not form aberrant connections with motor neurons. Inhibitory synapses from G2 to motor neurons are still present in these mutants. In NB2−/− or NrCAM−/− mice, the number of inhibitory synapses from G1 to sensory neurons is significantly reduced but G2 interneuronal contacts onto motor neurons remain unaffected. G1: GABAergic neurons; G2: GABAergic and/or glycinergic neurons. Summarized from [21, 22]