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. Author manuscript; available in PMC: 2018 Jun 7.
Published in final edited form as: Ageing Res Rev. 2016 Jun 25;29:90–112. doi: 10.1016/j.arr.2016.06.005

Fig. 9.

Fig. 9

Confidence view of the predicted and know protein and chemical interactions. Stronger associations are represented by thicker lines. Protein-protein interactions are shown in blue, chemical-protein interactions in green and interactions between chemicals in red. ZFR – zinc finger RNA binding protein. FCGR3B – Fc fragment of IgG, low affinity IIIb, receptor (CD16b). ARL6IP6 – ADP-ribosylation-like factor 6 interacting protein 6. EML4 – echinoderm microtubule associated protein like 4. S100A8 – S100 calcium binding protein A8. C4B – complement component 4B. Predicted functional partners include catalase, SOD2 – superoxide dismutase 2; SOD3 – superoxide dismutase 3; NOS3 – nitric oxide synthase 3; GPX1 – glutathione peroxidase 1; AKT1 – v-akt murine thymoma viral oncogene homolog 1; GPX2 – glutathione peroxidase 2; NOX4 – NADPH oxidase 4; NOX5 – NADPH oxidase, EF-hand calcium binding domain 5; TYRP1 – tyrosinase-related protein 1. A more comprehensive and in-depth study of all the modified proteins during aging may yield strong known and/or predicted protein and chemical interactions. Data obtained using STITCH (Kuhn et al., 2014).