Figure 5.

RT and genome organization control during development. RT asynchrony loss is coordinated with a decrease in genome organization differences between alleles. Genome tracks of RT (two cell lines with opposite parental configurations), Hi-C eigenvectors, ATAC-seq, and total nuclear RNA-seq are shown for mESCs (blue/gray) and for NPCs (red/orange). Differences in RT and Hi-C compartments are lost during differentiation to NPCs. NPC ATAC-seq, RNA-seq, and Hi-C data were obtained from Giorgetti et al. (2016).