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A, Diagram illustrating recruitment of patients with severe OSA and healthy control subjects in the case-finding study. B, Diagram illustrating recruitment of patients with severe OSA in the closure study. AHI = apnea-hypopnea index; CVA = cerebrovascular accident; NPSG = nocturnal polysomnography; OSA = obstructive sleep apnea; PFO = patent foramen ovale; TIA = transient ischemic attack.
