Table 4.
Comparison of Patients With OSA With and Without Clinically Significant Shunting Through PFO
| Characteristic | Clinically Significant Shunt (n = 26) | Clinically Insignificant or No Shunt (n = 74) | P Value |
|---|---|---|---|
| Age, y | 54 (9) | 51 (10) | .20 |
| BMI, kg/m2 | 34.2 (7.2) | 34.6 (6.1) | .77 |
| FEV1, % predicted | 92 (16) | 93 (11) | .67 |
| FVC, % predicted | 93 (13) | 94 (11) | .63 |
| FEV1/FVC | 81 (6) | 80 (5) | .65 |
| AHI, events/h | 46.8 (14.3) | 56.5 (18.3) | .01 |
| ODI, events/h | 48.6 (16.1) | 49.8 (22.5) | .78 |
| ODI/AHI | 1.05 (0.27) | 0.86 (0.26) | .004 |
| Percentage time SaO 2 < 90%a | 27 (25) | 26 (25) | .85 |
| 6MWT distance, m | 511 (138) | 564 (83) | .07 |
| PaO 2, kPa | 11.8 (1.4) | 11.6 (1.2) | .43 |
| PaCO 2, kPa | 5.1 (0.5) | 5.4 (0.5) | .02 |
| Epworth Sleepiness Score | 11 (6–15) | 7 (4–12) | .08 |
| HIT6 headache score | 48 (38–55) | 40 (36–50) | .09 |
| SF-36v2: physical component | 43 (13) | 48 (10) | .10 |
| SF-36v2: mental health component | 45 (12) | 50 (9) | .08 |
Values expressed as mean (SD) or median (range). 6MWT = 6-min walk test. See Table 1 legend for expansion of other abbreviations.
a
Values expressed for 23 of 26 patients with clinically significant shunt and 64 of 74 patients with clinically insignificant or no shunt.