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Chronic itch and depression are reciprocal causation and interaction deterioration. (a–c) Mice in group A (DNFB+CUMS) showed more depressive behaviors than those in group B (DNFB) and group C (CUMS) in the FST (a), TST (b) and ST (c) tests. (d) The scratch number in group A was significantly increased compared to that in group B and C. *p < .05 versus Group B; **p < .01 versus Group A or C. CUMS, chronic unpredicted mild stress; FST, forced swimming test
