Figure 4.

Cntn6 deficiency improves spatial relearning of female mice. (a) Representative traces of swimming plot in Morris water maze reversal task. (b) Quantitative analyses of the Morris water maze. Performance of Cntn6 ^−/− male mice (2–4 months) in the spatial relearning phase of the Morris water maze task, as measured by escape time to platforms. n = 10 (WT), 14 (Cntn6 ^+/−), 9 (Cntn6 ^−/−). (c) Performance of Cntn6 ^−/− female mice in spatial relearning. n = 8 (WT), 12 (Cntn6 ^+/−), 8 (Cntn6 ^−/−). Data represent mean ± SEM. Two‐way ANOVA followed by Bonferroni posttest. *, p < .05; ***, p < .001