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. Author manuscript; available in PMC: 2018 Jun 7.
Published in final edited form as: Mol Psychiatry. 2016 Nov 15;22(8):1134–1139. doi: 10.1038/mp.2016.209

Figure 2.

Figure 2

Effects of aggregate OXTR risk on functional connectivity (z>2.3, P<0.01, cluster corrected for multiple comparisons at P<0.05). (a) TD group: areas showing greater connectivity with the NAcc as a function of greater numbers of OXTR risk alleles. No increased functional connectivity with the NAcc as a function of OXTR risk alleles was observed in the ASD group (not shown). (b) ASD group: areas showing less connectivity with the NAcc as a function of greater OXTR aggregate risk. No decreased functional connectivity with the NAcc as a function of OXTR risk alleles was observed in the TD group (not shown). Scatterplots are shown for illustrative purposes and represent connectivity values extracted from the regions displayed at left as a function of number of OXTR risk alleles. See also Supplementary Table 2. ASD, autism spectrum disorder; NAcc, nucleus accumbens; OXTR, oxytocin receptor gene; TD, typically developing.